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Nicole Wilson completed her undergraduate degree in Neuroscience at the University of Calgary, conducting research under the supervision of Dr. Sabine Gilch in the Department of Veterinary Medicine. Her research focused on the role of cholesterol metabolism in the pathogenesis of prion diseases, a group of fatal and infectious neurodegenerative disorders affecting both humans and animals. Nicole’s findings suggested that elevated cholesterol synthesis observed in cells upon prion infection may function as a protective mechanism to rescue neuronal cells from disease states, providing new insights into how prion infection modulates fundamental cellular processes.
Following her undergraduate studies, Nicole earned an MPhil in Basic and Translational Neuroscience at the University of Cambridge, where she conducted research in the lab of Dr. Edward Avezov at the UK Dementia Research Institute. Utilizing advanced techniques such as fluorescence lifetime imaging microscopy (FLIM) and electron microscopy (EM), Nicole investigated how endoplasmic reticulum (ER) morphology affects mitochondria-ER contact sites (MERCs), mitochondrial calcium levels, and mitochondrial bioenergetics in the context of neurodegenerative diseases.
Nicole is currently a Research Associate at General Proximity, working with the Platform and Biology team to generate a novel class of bifunctional therapeutics. When not in the lab, Nicole enjoys bouldering, discovering new cafes, and playing D&D with friends.
