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Corentine M. C. Laurin is an experienced medicinal chemist who is dedicated to advancing novel therapeutics through her scientific and strategic insight. She received her Medicinal Chemistry Masters from Glasgow University working on the synthesis of mitochondrial prodrugs with Prof. Richard Hartley. She completed her PhD at Oxford University, working on bromodomain inhibitors and assay development in the lab of Dr. Stuart Conway for the treatment of Chagas disease, leading to the publication of multiple papers on the development and optimisation of ligands for various epigenetic targets. Her scientific training included industry experience at Hoffmann-la Roche (Basel, Switzerland) where she elucidated the SAR of an antiviral series, and at GlaxoSmithKline (Stevenage, UK) where she designed and synthesized fluorescent probes for T. cruzi bromodomains.
Following a natural progression from developing bromodomain inhibitors utilizing them as degrader ligands, Corentine went on to perform her postdoctoral studies at Yale in the lab of Prof. Craig Crews. She led ligand discovery efforts for an undruggable target, and increased screening capabilities within the Crews lab by establishing covalent ligand screening. She worked on the design and synthesis of three separate of proximity inducing drugs modalities (including PROTACs and molecular glue prodrugs).
As a Principal Scientist at General Proximity, Corentine leads the chemistry team, managing both internal researchers and multiple synthetic contract research organizations (CROs). She oversees the design of new molecules, targets, and screening priorities, as well as the analysis of biological data. Additionally, she co-leads compound optimization efforts focusing on efficacy, pharmacokinetics, and pharmacodynamics, and plays a pivotal role in shaping the company’s intellectual property strategy.
Outside of her professional pursuits, Corentine enjoys hiking, learning new languages, and spending quality time with her daughter.
