We’ve built the first generalized, mechanism-agnostic, proximity discovery engine.

Our genomes code for thousands of intricate molecular machines—effector proteins—which regulate all aspects of biology. These include chaperone, adaptor proteins, and trafficking proteins, all post-translational modification (PTM) readers/writers/erasers, and many others.

In aggregate, these effector proteins comprise the ‘effectome’: the set of all proteins which modulate other proteins to control biology.

To us they represent something even more: a boundless array of untapped biological tools.

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Proximity is a master regulator of biology. All biological processes are controlled through proximity on some level.

Interactions or ‘proximity events’ between ‘target’ and ‘effector proteins’ can result in a vast constellation of downstream biology on a target protein—activation, refolding, re-localization, re-programming, functional modulation, degradation, etc. Manipulation of a given protein’s proximity topology thus enables nearly arbitrary control of that protein's function and biology.

Our unbiased effector discovery platform allows us to discover the most powerful proximity mechanisms for a given target, enabling the development of highly-efficacious proximity therapeutics for targets previously beyond the reach of medicine.

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